Qiaojie Xiong

Associate Professor
PhD, Johns Hopkins University

qiaojie.xiong@stonybrook.edu 

Life Sciences Building
Office: Room 540
Lab: Room 565
Phone: (631) 632-9877
Fax: (631) 632-6661

Lab website: https://www.stonybrook.edu/commcms/gxlab/

 

 

Training

Qiaojie Xiong received undergraduate degree in biological science from University of Science and Technology of China. She then attended the Johns Hopkins University, school of medicine, where she received Ph.D. in Physiology. She was a postdoctoral fellow in Cold Spring Harbor Laboratory from 2008 to 2015. She joined the faculty of the Department of Neurobiology & Behavior at Stony Brook University in 2015.

Research Interests/Expertise

My laboratory studies the neural mechanisms underlying auditory-guided behaviors. Dorsal striatum is a key brain region in sensory-guided behaviors including decision-making and learning. We initiated a series of investigations to determine how neural circuits connecting the auditory striatum, a posterior sub-region of the dorsal striatum, regulate auditory-guided behaviors including: 1) transformation from auditory cues to motor action; 2) modulation of attention and vigilance states on auditory processing; and 3) learning induced changes in the circuitry that enable the association between auditory cues and motor actions. We use interdisciplinary and state-of-the-art approaches including rodent behavioral paradigms, in vivo and in vitro electrophysiological recordings, in vivo calcium imaging, and chemogenetic and optogenetic techniques to arrive at information about structure/function relationships that support auditory-cued behaviors at their highest levels.

• Publications

  Xiong Q, Znamenskiy P, Zador AM. Corticostriatal plasticity underlying acquisition of an auditory discrimination task. Nature 521(7552):348-51 (2015)

  Xiong Q, Oviedo HV, Trotman LC, Zador AM. PTEN regulation of local and long-range connections in mouse auditory cortex. J Neurosci. 32(5):1643-52. (2012)

  Xiong Q, Sun H, Zhang Y-M, Nan F-J, Li M. Combinatorial augmentation of voltage-gated KCNQ potassium channels by chemical openers. Proc Natl Acad Sci U S A. 105(8):3128-33 (2008)

  Xiong Q, Gao Z, Wang W, Li M. Activation of Kv7 (KCNQ) voltage-gated potassium channels by synthetic compounds. Trends Pharm Sci. 29(2): 99-107. (2008)

  Xiong Q, Sun H, Li M. Zinc pyrithione-mediated activation of voltage-gated KCNQ potassium channels rescues epileptogenic mutants. Nat Chem Biol. 3(5):287-96. (2007)